FISH FOR WOLF HIRSCHHORN SYNDROME (WHS) OR 4P DELETION

Description

Fluorescence in situ hybridization (FISH) is a genetic test used to diagnose Wolf-Hirschhorn Syndrome (WHS), also known as 4p deletion syndrome. WHS is caused by a deletion of genetic material on the short arm (p arm) of chromosome 4, specifically in the 4p16.3 region. FISH utilizes probes that bind to specific DNA sequences on chromosome 4, allowing for the detection of deletions in this region.