FISH FOR TEL-AML /ETV6-RUNX1 / T(12;21)

Description

FISH (Fluorescence In Situ Hybridization) is a molecular cytogenetic technique used to detect the ETV6/RUNX1 (also known as TEL/AML1) fusion gene resulting from the t(12;21)(p13;q22) translocation. This translocation is a common genetic abnormality in childhood B-cell precursor acute lymphoblastic leukemia (ALL), found in approximately 25% of cases. FISH is the preferred method for detecting this translocation because it is frequently undetectable by standard cytogenetic methods. .