FISH FOR SRY DELETION/TRANSLOCATION

Description

FISH for SRY (Sex-determining Region Y) deletion or translocation is a molecular cytogenetic technique used to detect abnormalities in the SRY gene, which is crucial for male sex determination. It helps identify deletions or mislocalizations of the SRY gene on the Y chromosome, which can lead to disorders of sex development (DSD). The technique uses fluorescently labeled DNA probes that bind to specific sequences on the chromosomes, allowing for visualization of the SRY gene and its location.