FISH FOR INVERSION 16 (CBFB)/T(16;16)

Description

FISH (Fluorescence In Situ Hybridization) is a molecular cytogenetic technique used to detect specific genetic abnormalities, including the inversion (16) and translocation t(16;16) in acute myeloid leukemia (AML). These abnormalities involve the CBFB and MYH11 genes and are often associated with the M4Eo subtype of AML. FISH is useful for both diagnosis and monitoring of the disease, particularly in cases where conventional cytogenetics may not detect subtle rearrangements.