FISH FOR HYPER-EOSINOPHILIC SYNDROME (4Q12) (FIP1L1-PDGFRA)

Description

FISH (Fluorescence In Situ Hybridization) for FIP1L1-PDGFRA is a genetic test used to diagnose a specific type of hypereosinophilic syndrome (HES) or chronic eosinophilic leukemia. It detects a genetic rearrangement on chromosome 4q12, specifically the FIP1L1-PDGFRA fusion gene, which is a hallmark of this condition. This test helps identify patients who are likely to respond to treatment with imatinib, a tyrosine kinase inhibitor.