PML/RARA (AML – M3) (APML)

Description

PML/RARA, also known as Acute Promyelocytic Leukemia (APL) or AML-M3, is a specific subtype of acute myeloid leukemia (AML) characterized by a chromosomal translocation that fuses the PML gene on chromosome 15 with the RARA gene on chromosome 17. This fusion creates a PML/RARA oncoprotein that disrupts normal myeloid cell maturation, leading to the accumulation of abnormal promyelocytes in the bone marrow